GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs6684514 | 1 | rs10908502 | chr1:156300082 | BGLAP | chr1:156182784-156213112:+ | 0.22 | 3.84 | 0.000145 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BLCA | cis | rs11799420 | 1 | rs10913582 | chr1:171715585 | VAMP4 | chr1:171669298-171711214:- | 0.3 | 4.28 | 2.35E-5 | Hippocampal atrophy |
| BLCA | cis | rs10917151 | 1 | rs10917151 | chr1:22422721 | HSPC157 | chr1:22351707-22357713:+ | -0.29 | -3.9 | 0.000114 | Endometriosis |
| BLCA | cis | rs10935120 | 1 | rs10935120 | chr3:134233092 | ANAPC13 | chr3:134196547-134204865:- | -0.45 | -7.12 | 5.51E-12 | Height |
| BLCA | cis | rs1577917 | 1 | rs10944161 | chr6:86630376 | SNHG5 | chr6:86386726-86388451:- | -0.51 | -9.01 | 9.54E-18 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs10944163 | chr6:86658693 | SNHG5 | chr6:86386726-86388451:- | -0.54 | -9.35 | 7.6E-19 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs10944169 | chr6:86683036 | SNHG5 | chr6:86386726-86388451:- | -0.5 | -8.88 | 2.56E-17 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs10944170 | chr6:86685469 | SNHG5 | chr6:86386726-86388451:- | -0.49 | -8.64 | 1.49E-16 | Response to antipsychotic treatment |
| BLCA | cis | rs9457247 | 1 | rs10946198 | chr6:167404432 | RNASET2 | chr6:167343008-167412795:- | -0.25 | -5.15 | 4.08E-7 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs10946199 | chr6:167404492 | RNASET2 | chr6:167343008-167412795:- | -0.25 | -5.19 | 3.37E-7 | Crohn's disease |
| BLCA | cis | rs7611238 | 1 | rs1094677 | chr3:195129744 | C3orf21 | chr3:194789015-194991895:- | -0.28 | -5.38 | 1.28E-7 | Body mass index |
| BLCA | cis | rs2243480 | 1 | rs10950032 | chr7:65738591 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.72 | 3.27E-6 | Diabetic kidney disease |
| BLCA | cis | rs10464366 | 1 | rs10951593 | chr7:39121390 | RALA | chr7:39663162-39747715:+ | 0.27 | 4.6 | 5.64E-6 | IgG glycosylation |
| BLCA | cis | rs7005380 | 1 | rs10955943 | chr8:120944143 | DEPDC6 | chr8:120885900-121063156:+ | -0.25 | -3.97 | 8.61E-5 | Interstitial lung disease |
| BLCA | cis | rs12220238 | 1 | rs11000887 | chr10:75897542 | ADK | chr10:75910965-76469059:+ | 0.3 | 4.47 | 1.02E-5 | Soluble interleukin-2 receptor subunit alpha |